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Synovitis synovial changes thickening and swells

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Synovitis:Synovial Changes → → → → → →Thickening and swellsBlood vessel involvementDecreased vascular flowIncreased metabolic needsAcidosis and enzymensDamages articular cartilageTendon and ligament inflammationSynovial fluid becomes thin, cloudywith WBC and proteinWhich Becomes Pannus TissueSynovial tissue thickens causingvascularity to clot/thicken causingpannus tissue to formEventually leads to scar formationwhich immobilizes jointAdhesions from, bone calcification,destructions and loss of bonedensity and secondary osteoporosis
N151 - Exam 2 - Urinary Disorders, Menstrual Dysfunction, Peri & Menopause, BPH, RA, SLE, AKI, CKD, Dialysis, Transplant, TIA & Stroke -13CausesGenetic factorsEnvironmental factorsHormonal factors - women 3x more likelyVirusImmunologic factors - antigen exposureStress - physical or emotionalSmoking - quitting decreases chancesRisk FactorsFHx of RAHeavy smokers**Absence of risk factors does not meanthat you will not develop RA**Across the LifespanPregnancy - may see remission during gestation - relapse after delivery = hormones?Estrogen exacerbates / androgen helpsPromote ROM and restStop taking RA meds - teratogenicChildren - JIA - Juvenile Idiopathic Arthritis. (aka Juv RA) - 3-6yo and pubertyUnknown cause, hormonal?Often no complaint of pain but see differences in gait, prolonged stiffness at waking.Promote exercise and rest. Exercise can slow progressionLikely to go into remission in adulthood(Risk of Rye Syndrome: use of aspirin with flu like symptoms or chicken pox)Older Adults - too much rest = immobility/stiffness of joints and permanent loss of function.Main treatment is to maintain function and decrease joint deformity.Meds can be more toxic to elderly pts.S/SLow grade feverWeight loss - anorexiaFatigueAnemiaLymph node enlargementNodules over bony prominences or in SQ -firm and filled with necrotic tissue calledgranulomatosis lesions“Boggy,” heat, pain, tenderness of jointsSwan neck deformity - hyperextension ofthe PIP joint with a compensatory flexion ofthe DIP joint - ulnar deviation of the fingers.Boutonniere’s deformity - flexion of PIP withan extension of the DIP.Raynaud’s Phenomenon - compromiseblood flow to fingertips - yellow or whiteNeuropathySplenomegaly/neutropenia (enlargedspleen, low WBC)Sjogren’s Syndrome - dry eyes and mucousmembranes. Body attacks lacrimal andsalivary glands. Vaginal dryness.Vasculitis or pericarditisIncreased risk of CAD - low HDL, high LDL,HTNIncreased C Reactive ProteinAssessmentPast and family Hx of autoimmune diseaseHx smokingPainImmunizations and AllergiesStressPresences of deformities - especially inhandsWeakness in the AM >1hrSkeletal atrophyDecreased ROM and fatigue
N151 - Exam 2 - Urinary Disorders, Menstrual Dysfunction, Peri & Menopause, BPH, RA, SLE, AKI, CKD, Dialysis, Transplant, TIA & Stroke -14Diagnostic Tests- Rule out other diseaseCBC - inflammation / WBC - elevated, mild anemiaRheumatoid Factor - normally neg.

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Term
Fall
Professor
N/A
Tags
SLE, BPH, menstrual dysfunction

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