Parts of a neuron terminal terminals have many of the

Info icon This preview shows pages 12–19. Sign up to view the full content.

View Full Document Right Arrow Icon
Parts of a Neuron-terminal Terminals have many of the organelles that are localized in the nucleus In particular, the terminals contain mitochondria (energy) as well as enzymes to synthesize neurotransmitters Terminals can make contact with dendrites, axons and other terminals
Image of page 12

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Exocytosis of synaptic vesicles into the synaptic cleft (extracellular fluid)
Image of page 13
Release of Neurotransmitters SNAREs: vesicle-associated membrane protein (VAMP) or synaptobrevin (on vesicle so v-SNARE) syntaxin (in active zone t-SNARE (target)) synaptosomal-associated protein of 25 kDa (SNAP-25) (in active zone=t-SNARE) Toxins and Vesicular Release Botulism: “protase”; cleaves t- and v-SNAREs Tetanus: Protase; inhibits v-SNAREs cause inhibition of release paralysis
Image of page 14

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
“Reserve Pool” Synapsins: -Bind to vesicles and anchor them to actin -their activation by kinases causes them to dissociate from vesicles -vesicles move to active zone
Image of page 15
Calcium’s role in Release - Synaptotagmin : Calcium-sensing protein that is anchored to the vesicle membrane; has 2 calcium-sensing regions on its cytoplasmic region -regulated by complexins
Image of page 16

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Ending Neurotransmission -2 major mechanisms to end neurotransmission 1- reuptake : transporters in the terminals (or on the dendrites) take the neurotransmitter back inside the neuron to be re-packaged or degraded 2- enzymatic degradation : enzymes found in the synaptic cleft break down the neurotransmitter after it is released (oxidases, esterases=non-synthetic reactions) 3- diffusion : neurotransmitters simply move out of the synaptic cleft
Image of page 17
Policing Neurotransmission - Autoreceptors : receptors that are located on the edges of the active zone on the presynaptic terminal ; regulate calcium channels and the machinery involved in exocytosis
Image of page 18

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 19
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern