A statistically significant reduction was also seen

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A statistically significant reduction was also seen between the 4 weeks and the 12 weeks follow-up. These findings were true for both the test and the control group [Table 6 and Graph 6]. (Gengigel ® 0.8%, Ricerfarma) [Figure 2]. The test sites were then covered with a periodontal dressing (Coe-Pak ® ) for retention of the material [Figure 1c]. Each subject was told to report immediately if the pack was dislodged before the scheduled recall visit or if any sort of discomfort, pain, burning sensation, or any allergic reaction occurred. At the 1 st week recall, the same procedure was repeated. HA gel was readministered at the test sites after removing periodontal dressing. The periodontal dressing was placed again, and the instructions were repeated. Subjects were recalled after 7 days for removal of the periodontal dressing, reinforcing oral hygiene maintenance instructions, and recording clinical parameters. Recall visits were scheduled at the end of 4 weeks and 12 weeks. Statistical analysis A convenient sample size of 100 sites was included under 5% alpha error and 80% of power of the test to detect the significant difference. All data collected was entered in Microsoft Excel (MS office version 2010) and tabulated. Data analysis was done using Windows PC-based SPSS version 17 software (SPSS Inc., Chicago, IL, USA). The one-way analysis of variance was used to compare the intra-group parameters at various time intervals (baseline, 4 weeks, and 12 weeks) followed by Bonferroni post hoc test. The Student’s t -test was used to determine whether a statistically significant difference existed between the test and the control groups at different time intervals. Statistical significance was set at 5% level of significance ( P < 0.05). RESULTS One hundred sites were selected from nine patients, showing PPD ≥5 mm in at least one tooth in the contralateral quadrants. These patients, in the age group of 30–60 years, satisfied the inclusion criteria of having chronic periodontitis. All subjects completed the study. The periodontal parameters were assessed at baseline, 4 weeks, and 12 weeks. For PI and GI, site-specific scores were recorded and tabulated. For PPD and RAL, the deepest probing depth and its corresponding RAL, for the selected tooth, were recorded and tabulated. These recordings were subjected to both intra- and inter-group comparisons. Plaque index Inter-group comparisons of PI at each follow-up revealed no significant difference between the groups at any stage during the follow-up as seen in Table 1 and Graph 1. Comparison at Figure 2: 0.8% hyaluronic acid gel (Gengigel ® Prof Syringes, Ricerfarma) Figure 1: (a) Pocket Probing with stent in position; (b) Application of 0.8% Hyaluronic acid gel with blunt cannula; (c) Periodontal dressing placed c b a [Downloaded free from on Friday, September 15, 2017, IP: 36.79.172.174]
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Shah, et al .: Hyaluronan as local drug delivery 4 Journal of Indian Society of Periodontology Graph 1: Inter-group comparison of plaque index Graph 3: Inter-group comparison of gingival index
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  • Fall '19
  • Statistical significance, SRP, Periodontitis, Hyaluronan

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