Evaluation criteria at 18 months after inclusion the

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ended when this number was reached. Evaluation criteria at 18 months after inclusion. The primary outcome criterion was the Morgan and Russell outcome category (good or intermediate outcome versus poor outcome) at 18 months. The secondary outcome indicators were the GOAS total score, AN symptoms or their consequences (BMI, amenorrhea, EDI scores), social adjustment and the number of hospitalizations in the course of follow-up. The effect size was evaluated for qualitative variables by the odd ratio and its confidence interval as recommended by Fleiss et al [51] and for quantitative variables by Cohen’s d test. Between-group comparisons. Treatment groups were compared on socio-demographic and clinical characteristics at baseline and at 18 months of follow-up. Completeness of follow-up data. Fifty-six participants were seen at 6 months, 49 at 12 months, and 55 at 18 months. Five were not seen at 18 months: 2 in the TAU group and 3 in the TAU + FT group. Of these 5 participants, only one was completely lost to follow-up, 2 were seen only at 6 months, and 2 were seen for the last time at 12 months. Missing data were modeled using the Last Observation Carried Forward (LOCF) procedure, which enabled the inclusion of 59 participants (29 TAU; 30 TAU + FT). We first realized Intention to Treat Analyses (ITTA) and then Per Protocol Analysis (PPA). For the ITTA, randomized patients who didn’t receive any treatment were included in the analyses and these patients were followed up in the trial. For PPA, in line with Russell’s et al. trial [16], only those who attended more than three sessions of FT were considered in the analyses. Accordingly, 53 received the treatment provided for in the protocol (Figure 1). Among the TAU + FT participants, 4/30 (13.3%) did not receive FT ( # 3 FT sessions). Conversely, 2/30 of the TAU participants (6.7%) did in fact receive FT prescribed by there psychiatrist (outside the trial) due to a context of family crisis; 1 was lost to follow-up (Figure 1). Therefore, the PPA compared 27 TAU with 26 TAU + TF. Analyses. The two treatment groups were compared at 18- months of follow-up with an alpha risk of 0.05 for two-sided tests. The Chi 2 or Fisher Exact Probability tests were used for the categorical variables. Either Student t-tests or Mann-Whitney tests were used (as appropriate) for the continuous variables. Finally, we used matched series Student tests for intra-group comparisons exploring the evolution of quantitative criteria, and Mac Nemar tests for qualitative variables between inclusion and 18-months of follow-up. All tests were two-sided. Analyses were performed using SPSS 11. Results Participant characteristics Descriptive statistics of the 60 AN participants are presented in Table 1. There were 5 AN purging subtype in the TAU + FT group and 3 in the TAU group (no group effect, p = .71). At the start of the study, all the participants were on amenorrhea and the TAU and TAU + FT groups were comparable. The mean BMI at admission clearly indicates the seriousness of their condition (i.e., much lower than the third percentile: 16.23 kg/ m 2 for 16 to 16.4 year-old [47]). Both groups had a mean BMI at discharge over the 10 th percentile (i.e., 17 kg/m

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