Pharmacology I Study Guide-2.docx

Affecting mucoproteins and splitting the disulfide

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affecting mucoproteins and splitting the disulfide bonds; breaks down extracellular DNA from proteins Adverse effects: GI upset, stomatitis, bronchospasm Dornase alfa (Pulmozyme) Acetylcysteine (Mucomyst) Chapter 55: Drugs Acting on the Respiratory System: Lower Respiratory Tract Bronchodilators : dilate the airways; used in symptomatic relief or prevention of bronchial asthma and for bronchospasm assoc with COPD. Xanthines : have a direct effect on smooth muscles of the resp tract, both in bronchi and in blood vessels; directly affect the mobilization of calcium within the cell Adverse effects: watch theophylline levels; GI upset, irritability, tachycardia, brain damage Aminophylline Theophylline Sympathomimetics : drugs used to mimic the effects of the sympathetic NS, most are beta 2 selective agonists (specific to bronchi). ASSESS APICAL PULSE Adverse effects: CNS stimulation, GI upset, hypertension, bronchospasms, flushing Albuterol (Proventil) Epinephrine (emergencies!) Levalbuterol (Zopenex) (less adrenergic effects)
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Anticholinergics : used as a bronchodilator for individuals who are unable to tolerate sympathomimetics >not as effective but can provide relief; block the vagal effect and cause relaxation of the smooth muscles and bronchodilation Adverse effects: dizziness, HA, fatigue, dry mouth, palps, urinary retention Ipratropium ( in combo with albuterol for DUONEB) Inhaled Steroids : help to decrease bronchoconstriction and inflammation; decrease the inflammatory response in the airway; CANNOT BE USED IN EMERGENCIES Adverse effects: sore throat, hoarseness, cough, dry mouth Budesonide (Pulmicort) Fluticasone (Flovent) Beclomethasone (Beclovent) Advair Leukotriene Receptor Antagonists : help to decrease both bronchoconstriction and inflammation by blocking leukotriene production of D4 and E4 Adverse effects: HA, dizziness, abd pain, elevated liver enzymes, fever, myalgia, generalized pain Montelukast (Singulair) Mast Cell Stabilizers : help to decrease bronchoconstriction and inflammation; prevents release of inflammatory and bronchoconstricting substances Adverse effects: rarely used Cromolyn (NasalCrom) Lung Surfactants : maintain the surface tension of the alveoli by replacing the surfactant missing in neonates and RDS. Adverse effects: bradycardia, hypotension, pneumothorax, sepsis Beractant (Survanta) Poractant (Curosurf) Chapter 39: Drugs Acting on the Reproductive System Estrogen : effects are first noticed at menarche, female characteristics assoc, produced by the ovaries, decreased production with menopause Progesterone : released after ovulation, helps to support the development of the fetus, continuously released to support fetus
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GnRh (gonadotropin-releasing hormone) : stimulates the anterior pituitary to release FSH and LH to stimulate ovulation.
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  • Spring '16
  • Loren Martin
  • Adrenergic receptor

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