Pharmacokinetics Well absorbed widely distributed in the body Metabolized in

Pharmacokinetics well absorbed widely distributed in

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Pharmacokinetics Well absorbed, widely distributed in the body Metabolized in the liver and primarily excreted in urine
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Oral Decongestants (cont.) Oral Decongestants (cont.) Contraindications Any condition that might be exacerbated by sympathetic activity Adverse Effects Rebound congestion Sympathetic effects Drug-to-Drug Interactions OTC products that contain pseudoephedrine; taking concurrently can cause serious side effects
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Nursing Considerations for Oral Decongestants Nursing Considerations for Oral Decongestants Assess: History and Physical Exam and known allergy Pregnancy, lactation, hypertension, CAD Hyperthyroidism, diabetes mellitus, or prostate enlargement Orientation, reflexes, and affect VS and LS Prototype: Pseudoephedrine
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Topical Nasal Steroid Decongestants Topical Nasal Steroid Decongestants Actions- relieve inflammation Exact mechanism of action is not known Indications Seasonal allergic rhinitis Inflammation after the removal of nasal polyps Pharmacokinetics Generally not absorbed systemically
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Topical Nasal Steroid Decongestants (cont.) Topical Nasal Steroid Decongestants (cont.) Contraindications Acute infection Caution Active infection Avoid exposure to airborne infections Adverse Effects Local burning, irritation, stinging, dryness of the mucosa, and headache Suppression of healing can occur in a patient who has had nasal surgery or trauma
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Nursing Considerations for Topical Nasal Steroid Decongestants Nursing Considerations for Topical Nasal Steroid Decongestants Assess: History and Physical Exam and known allergy Nasal mucosa, respiration and adventitious sounds Temperature
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Prototype Topical Nasal Steroid Decongestants Prototype Topical Nasal Steroid Decongestants
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Antihistamines Antihistamines Relieve respiratory symptoms and treat allergies First-generation and second generation antihistamines include: Brompheniramine ( J-Tan ) Carbinoxamine ( Histex , Palgic ) Chlorpheniramine( Aller-Chlor ) and many others See table 54.3
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Antihistamines Antihistamines Actions Selectively block the effects of histamine at the histamine-1 receptor sites , decreasing the allergic response Anticholinergic and antipruritic effects Indications Seasonal and perennial allergic rhinitis, allergic conjunctivitis, uncomplicated urticaria, and angioedema Pharmacokinetics Well absorbed, metabolized in the liver, excreted in urine and feces Contraindications Pregnancy and lactation
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Antihistamines (cont.) Antihistamines (cont.)
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