11(10 and 20 μg/mL) is recommended for Vancomycin but not required for dalbavancin, oritavancin, or telavancin since the have bactericidal activity and a post antibiotic effect (PAE) ofone to four hours (Arcangelo et al., 2017). Vancomycin is given in neutropenic fever, endocarditis, and meningitis while the newer agents are used for the treatment of skin and skin structure infections (Arcangelo et al., 2017). The most reported side effects related to vancomycin administration are “fever and chills, phlebitis, and “red man” syndrome (pruritus; flushing of the head, neck, and face; and hypotension) which resolves when the drug is discontinued (Arcangelo et al., 2017). Vancomycin can be nephrotocix and ottoxics especially if given with aminoglycosides, amphotericin B, acyclovir, and cyclosporine (Arcangelo et al., 2017).OxazolidinonesThe oxazolidinones (Linezolid (Zyvox) and tedizolid (Sivextro))are synthetic antibiotic which disrupt bacterial protein synthesis and are efficient against gram-positive aerobic organisms (staphylococci, streptococci, and enterococci) and resistant pathogens (MRSA, penicillin-resistant streptococci and VRE) (Arcangelo et al., 2017). The oxazolidinones are well absorbed from GI tract without regards to food and the possible side effects are diarrhea, nausea, taste perversion, vomiting, anemia, leukopenia, and pancytopenia (Arcangelo et al., 2017). If patients receive linezolid for over two weeks a complete blood count should be ordered.
