CBDAcannabidiolic acidTHC 9 cannabigerol

Cbdacannabidiolic acidthc 9 cannabigerol

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(CBDA,cannabidiolic acid;THC, 9 ‐tetrahydrocannabinol;CBD,cannabidiol;CBG, cannabigerol) ProductsofBiosynthesisandDecarboxylation NeuropathologyofDrugAddictionsandSubstanceMisuse,Volume 1 ,1 st ed.,byPreedy (ed.),2016.Ch.62
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Cannabidiol(CBD)isoneofthemajorconstituentsof theplantanddoesnotpossessanyofthe psychotropiceffectsof 9 ‐THCbuthasseveral pharmacologicaleffectswhichhavebeenconfirmed in invitro assaysandinanimalandhumantests. AlthoughCBDiscommonlythoughtofasbeingnon‐ psychoactive,researchershavenowdemonstrated thatCBDexhibitsantipsychotic,anxiolytic(anxiety‐ reducing)andantidepressanteffects.Therefore, CBD istechnically“psychoactive”becauseitdoesaffect themind. ThemoreappropriateanswerisCBDis “notpsychoactivelikeTHC”. IsCannabidiol (CBD)Psychoactive?
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BCPisavolatileterpenethatactivatesCB 2 receptorsand maybeausefultherapeuticcompound. NeuropathologyofDrugAddictionsandSubstanceMisuse,Volume 1 ,1sted.,byPreedy (ed.),2016.Ch.62 StructureandKeyFactsabout Beta‐Caryophyllene ,aNon‐Cannabinoid (BCP)
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Syntheticcannabinoidsincludeavarietyofdistinct chemicalstructuresandcanbedividedintotwomain classes:the classical cannabinoids ,structurallyrelatedto THCs,andthe nonclassical cannabinoids (cannabimimetics) structurallyunrelatedtoTHCs. ManyhundredsofnewTHCderivativesweremadeduring 1950sand1960s.Itprovedimpossibletoseparatethe desiredpropertiesofTHC(antinausea,painrelieving)from theintoxicatingeffects. Nevertheless,thechemicalresearchprovidedadetailed insightintothestructureactivityoftheTHCmolecule. Severalderivativesprovedtobeevenmoreactivethan THC. SyntheticCannabinoids
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CannabinoidAgonists Nantradol :thefirstpotentsyntheticTHCanalog;foundtohave analgesicproperties Levonantradol :theactiveisomerin Nantradol ;morewater solubleandthuseasiertoformulateanddeliverasapotential medicine;projectdroppedduetopsychoactivesideeffects Nabilone :theonlysyntheticTHCanalogdevelopedand approvedasamedicine,soldunderthetradename Cesamet CP55,940 :possessingonly2ofthe3ringsofTHC;widelyused asavaluableresearchcompound CannabinoidAntagonists SR141716A :Thefirstcannabinoidantagonist(forCB 1 receptors) tobedescribed,nowcalled rimonabant ; avaluableresearch tool ExamplesofSyntheticCannabinoids
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Syntheticcannabinoidsweredevelopedasresearchtoolstoexplore thefunctionoftheendocanabinoid systemandaspotential therapeuticagents. ManysyntheticcannabinoidsarenowclassifiedasScheduleIdrugs undertheUSControlledSubstanceAct. NeuropathologyofDrugAddictionsandSubstanceMisuse,Volume 1 ,1 st ed.,byPreedy (ed.),2016.Ch.71 SomeKnownPhysiologicalEffectsof SyntheticCannabinoids
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  • Spring '17
  • YU-FUNG LIN
  • Cannabis, Cannabinoid, Cannabaceae

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