It has been shown too that the cardiac out put and

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It has been shown too that the cardiac out- put and cardiac index of normal subjects with hypertensive parents are large before smoking as compared with the controls. On smoking they increased twice as much in normal sub- jects with hypertensive parents as in the con- trols, and they increased less in normal sub- jects whose parents had coronary disease thain in the controls. From the various findings coronary disease seems to occur more frequently and at an earlier age in the heavv smoker than in the nonsmoker. SUMMARY Ill normal sUbjects smoking or the inIjection of nicotine produces transient vascular effects on the heart and blood vessels. Apparently tobacco angina or tobacco heart is a clinical entity. Abnormal vascular responses after smoking in normal subjects may be due to hypersensitivity to nicotine, such as occurs ill tobacco heart, or to the effect of nicotine on a vascular svstem demonstrated to be hyper- reactive by the cold pressor test. Tobacco is one of the most prominent con- tributing factors in thromboangiitis obliterans, as thromboangiitis is rarely found in non- smokers. The question as to whether the effects of smoking are due to sudden increased work of the heart or constriction of the coronary artery has stimulated a great amount of re- search. There is evidence to support both theories. The findings of abnormal ballistocardio- grams before and after smoking in the off- spring of hypertensive parents and after smoking in the offspring of parents with coronary heart disease are highly important. Statistically coronary artery disease seemis to occur more frequently and at an earlier age in the person who smokes much than in the nonsmoker. Likewise, the mortality rate is higher among younger persons with coronary disease who are smokers than among those who are nonsmokers. SUMMARIO IN ITERIANGUA In subjectos normal, fumar o injection de nicotina produce transiente effectos vascular in corde e vasos de sanguine. Apparente- mente, "angina a tabaeo" o "corde a tabaeo" es un entitate clinic. A iiormnal responsas vascular a fumar occurrente inl subjectos nor- mal pote esser le consequentia de hypersensi- bilitate a nicotina (del genere occurrente ill "corde a tabaeo") o del efeccto de iiicotinla super un systemIa vascular quc se muonstrla hyperreactive in le test pressori a frigido. Tabaco es un del plus importante factores contributori in le causation de thromboangiitis oblitterante, visite que throiinboanigiitis se trova rarmente in non-funmatores. Le question de saper si le effectos del fuaiar es le consequentia de un subite augmento del labor del corde o del constriction del arteria coronari ha stimulate nuinerosissine investiga- tiones. 11 existe datos in su)porto del un e in supporto del altere theoria.

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