cholsterol metabolism Pharm 11-6-12

Chylomicra vldl getting rid of cholesterol 1 bile

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Chylomicra VLDL
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Getting rid of cholesterol 1. Bile Liver 2. Lipoproteins Liver & Gut 3. Storage all cells, limited 4. Efflux all cells, limited 5. Oxysterols all cells, limited 6. Steroid hormones endocrine cells
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Conversion to bile acids Cholic Chenodeoxycholic Bile acids are more soluble Bile acids are toxic in high concentration 450 450 450 450
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Conjugated Bile Acids Gluco cholic acid Tauro cholic acid
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Bile is composed of both bile acids and cholesterol ABCG5/8 BSEP to gut where most is reabsorbed
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Gall Stones cholesterol can become insoluble in bile
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An important balance Bile acids are necessary for adequate removal of cholesterol from the body. Bile acids help make cholesterol more soluble in bile. Bile acids help you reabsorb cholesterol. We are better designed to conserve cholesterol than to remove it
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Secondary bile salts are made in the gut from primary ones Deoxy cholic acid Produced by intestinal bacteria from primary bile acids in the gut
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Why remember bile acid synthesis? Important properties in digestion of fats Drugs that reduce gut absorption of bile acids reduce serum cholesterol levels One secondary bile acid is used to prevent gall stones (ursodeoxycholic acid) Another has been implicated as carcinogens (deoxycholic acid) The transformation & elimination of cholesterol into a bile acid is the same process used by the body to eliminate many orally absorbed drugs.
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3. Which statement is TRUE? Cells eliminate exces... Most of the sterols in ... Excess bile acids are ... Cholesterol is transf... 25% 25% 25% 25% 1. Cells eliminate excess cholesterol as fuel. 2. Most of the sterols in bile are excreted. 3. Excess bile acids are transformed into cholesterol. 4. Cholesterol is transformed into bile.
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Know The physical properties and chemical structure of cholesterol and bile acids. How cells acquire these molecules from the gut. How cholesterol synthesis is tied to energy metabolism and bile acid metabolism. That LDL-receptors, cholesterol synthesis and bile acids are regulated together. How cholesterol and bile are eliminated.
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Questions?
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