MICRO
CNS (1).pptx

Anticholinesterases satisfactorily control only

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Anticholinesterases satisfactorily control only relatively mild disease. 405
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B) Immunosuppressants :- Corticosteroids: For patients with myasthenia with moderate to severe generalized weakness who is responding inadequately to anticholinesterase drugs , the l ong term administration of corticosteroids is the most consistently effective form of t/t . Corticosteroids are also useful in :- In patients with occular myasthesia Those over the age of about 50 years with generalized disease. Patients without anti Ach R antibodies. In these patients the next approach to t/t is corticosteroids. 406
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Other drugs which can be used to supplement corticosteroids are:- Azathioprine Mycophenolate. Cyclophosphamide. 407
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Plasma exchange and transfusion - Its use is indicated in:- Severe myasthenia that is refractory to treatment with anticholinesterase drugs and prednisone Or during an acute worsening. Striking temporary remissions are obtained by the use of plasma exchange. 408
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Drug of choice for myasthenia gravis (PG1 Dec 99) a) Gallamine b) Succinylocholine c) D. tubocurare d) Pyridostigmine. D 409
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In myasthenia gravis, correct statement regarding thymectomy is - a) Should be done in all cases b) Should be done in cases with ocular involvement only c) Not required if controlled by medical management d) Should be done only in cases that are associated with thymoma 410
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Role of thvmectomv in patients with myasthenia gravis:- . “Thymectomy is an appropriate procedure in practically all patients with uncomplicated myasthenia gravis between puberty and 55 years of age”. 411
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412
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In myasthenia gravis, correct statement regarding thymectomy is – a) Should be done in all cases b) Should be done in cases with ocular involvement only c) Not required if controlled by medical management d) Should be done only in cases that are associated with thymoma A 413
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Which one of the following is correct regarding Eaton-Lambert syndrome- (AIIMS Nov 2004) a) It commonly affects the ocular muscle b) Neostigmine is the drug of choice for this syndrome c) Repeated electrical stimulation enhances muscle power in it d) It is commonly associated with adenocarcinoma of lung 414
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Lambert Eaton Myaesthenic syndrome: . It is a paraneoplastic syndrome associated with cancer particularly small cell Ca of lung. It is a disorder of neuromuscular junction transmission (Presynaptic). 415
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416
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Which one of the following is correct regarding Eaton-Lambert syndrome- (AIIMS Nov 2004) a) It commonly affects the ocular muscle b) Neostigmine is the drug of choice for this syndrome c) Repeated electrical stimulation enhances muscle power in it d) It is commonly associated with adenocarcinoma of lung C 417
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Treatment:- . The drug most effective in these patient is  3- 4 diaminopyrimidine.
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  • Winter '16
  • jean grey

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