Uses arrhythmias a fib atrial flutter SVT hypertension angina o MOA calcium

Uses arrhythmias a fib atrial flutter svt

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Uses: arrhythmias, a-fib, atrial flutter, SVT, hypertension, angina o MOA: calcium channel blockers o SE: hypotension, bradycardia, GI upset Chapter #24 – Antilipemic Medications (cholesterol lowering medications) Statins o Commonly taken to lower cholesterol o Atorvastatin, Simvastatin Uses: lower cholesterol/hypercholesterolemia, prevent MI MOA: increases HDL and decreases LDL SE: hepatotoxicity, muscle pain, GI upset, rhabdomyolysis Hepatotoxicity – common among all these classes – damage to liver Muscle pain – is also common with many Administer statin in evening with meal because cholesterol is synthesized at night Monitor liver function and CK levels Avoid alcohol while on medication Cholesterol Absorption Inhibitors o Ezetimibe Uses: lower cholesterol MOA: inhibits absorption of cholesterol in the small intestine Tip: “z” – causes cholesterol to zip on through SE: hepatotoxicity, muscle pain Monitor liver function and CK levels Bile acid sequestrants
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o Colesevelam Uses: lower cholesterol MOA: binds bile acids in intestine which causes excretion of cholesterol which lowers LDL cholesterol By removing bile from body, the liver has to make new bile and in order to do that it needs cholesterol, so it pulls it out of bloodstream SE: constipation increase fiber and fluids take with food and full glass of water Can interfere with absorption of fat-soluble vitamins (A, D, E, K) Can interfere with oral contraceptives Niacin o Nicotinic acid Uses: lower cholesterol, decreases lipoprotein and triglyceride synthesis in large doses and this in turn lowers LDL cholesterol and triglycerides SE: flushing of face, GI distress, hepatotoxicity, hyperglycemia Monitor liver function of hepatotoxicity Monitor BG levels because of r/f hyperglycemia Fibrates o Gemfibrozil Uses: MOA: decrease triglyceride production and transport and increases HDL SE: GI upset, gallstones, hepatotoxicity, muscle pain Give 30 mins before breakfast and dinner Monitor liver function and CK levels Chapter #25 – Medications affect Hematologic System IV Anticoagulants (parenteral) o Heparin, Enoxaparin (low molecular weight heparin) Uses: stroke, PE, DVT, any other conditions that require fast anticoagulation, prevents new clots from forming but won’t break up existing clots SE: bleeding *, heparin-induced thrombocytopenia (HIT) – see decrease in platelet count and increase formation of thrombi or clots in body, hypersensitivity When px on heparin we need to monitor their PTT levels (1.5-2x patients’ baseline) Baseline is usually 30-40 seconds Therapeutic PTT max would be about 80 (30-40x2) o If you get anything higher than 80 that is not therapeutic Antidote – protamine * Monitor s/s of bleeding (coffee ground emisis, black tarry stools) Encourage px to use soft bristled toothbrush and electric razor
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Oral anticoagulants o Warfarin (Coumadin)
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  • Spring '14
  • Bennett,SusanElizab
  • Bradycardia,  Sublingual

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