If the gfr is 125 mlmin but a drugs clearance is 200

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7. If the GFR is 125 ml/min but a drug’s clearance is 200 ml/min this means A. the drug must be reabsorbed as well as filtered. B. the drug must be secreted as well as filtered. C. the drug must be filtered especially thoroughly. D. the drug must be increasing blood perfusion of the kidney E. the patient must be bleeding internally in order to explain this rapid clearance. 8. Which portion of the nephron is most impermeable to water ? 9. Drug A is metabolized by a process involving zero-order kinetics while drug B is metabolized by a first-order processs. Which one of the following statements about drugs A and B is TRUE ? 10. Clearance could described in terms of which units listed below? 11. A patient is given (via iv injection) a dose of a drug with a half-life of 3 hours. Five hours later the drug concentration in the patient falls below the minimum therapeutic level. How long would it take for the drug concentration to fall to that same minimum therapeutic level if the patient was given twice that original dose? Assume first order kinetics are at work. A. 6 hours. B. 8 hours. C. 11 hours. D. 10 hours. E. 13 hours.
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  • Spring '08
  • Pharmacology, Nephron, Rate equation, Cytochrome P450

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