Each side can accommodate one unfolded protein 1

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Each side can accommodate one unfolded protein 1 GroES binds to one side of GroEL at a time Allosteric inhibition at other site One side of cylinder is actively folding protein at a time
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1. GroEL/ATP complex at side A 2. Bind GroES on this side 7 ATP 7 ADP this side has a wider cavity but closed top other side has smaller cavity and open top 3. Side B ring binds unfolded protein GroES falls off of side A ADP falls off of side A 4. Side B ring binds 7 ATPs 5. GroES binds GroEL/ATP 7 ATP 7 ADP protein folding occurs 6. Side A ring binds 7 ATPs protein folding occurs 7 ATP 7 ADP (side A) 7 ADP & GroES (side B) falls off 7. Side A ring binds next unfolded protein
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