Fusion – put everything together and increase temperature, then mix well o Trituration – mix drug with weighed amount of base using geometric dilution Drug should be soluble in the ointment base o If insoluble, varying dose, low permeation, and will be very gritty Quality requirements: o Uniform throughout o Free from grittiness Pharmaceutical Gels o Prepared with cellulose derivatives (methycellulose, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, hydroxypropylcellulose) o Factors affecting cellulose gel formation Temperature – cold water is used to solubilize them Precipitates when heated o When you put a clump in hot water, the outside solubilizes and hardens, leaving the inside still solid particles pH – this can change due to viscosity In ionized form, forms a close-knit structure Salts – change with viscosity Salt presence reduces viscosity o Pluronic 127 will be used in lab Forms very liquid structure in cold temperature but increases viscosity at room temperature Temperature sensitive gel i.e. restasis – for dry eye o Completely liquid product but when you put it in the eye, the viscosity increases and helps moisturize and keep the product in the eye for an extended period of time
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- Fall '09
- Colloid, Emulsion, Stratum Corneum, Formulate