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21 Lung Ventilation and Gas Exchange IV

Effect of exercise on ventilation and arterial gases

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Effect of Exercise on Ventilation and Arterial Gases and [H+] Arterial PCO2 is NOT the cause of hyperventilation during exercise
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Summary of Factors that Stimulate Ventilation During Exercise
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Altitude, Barometric Pressure, and Inspired PO2 (From: Ann. Intern. Med. 141: 789-800, 2004) Inspired PO2 = 0.21 x (Pb - 47)
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Morococha Andes Peru ~15,000 feet above Sea Level
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Oxygen at High Altitude 0 1 2 3 4 PO 2 in mmHg 0 50 100 150 Inspired gas Alveolar gas Arterial blood Venous blood Mitochondria sea level 15,000 feet
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Hypoxia-Induced Hyperventilation at High Altitude
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altitude arterial altitude venous At High Altitude, Loading and Unloading of Oxygen Occur on the Steep Part of Oxyhemoglobin Dissociation Curve
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What about at extremely high altitude, such as Mt. Everest?
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Regulation of Alveolar and Blood PO2 at Extremely High Altitude 0 1 2 3 4 in mHg 0 50 100 150 Inspired gas Alveolar gas Arterial blood Venous blood Mitochondria sea level Morococha PO2 o o o o Mt. Everest
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Oxygen Consumption (liters/min) 0 1 2 3 4 5 V en t i l a t i o n ( l i t e r s / m i n ) 0 20 40 60 80 100 120 140 160 180 Sea level "summit" Reduced Activity and Hyperventilation Are Necessary for Survival on Mt. Everest
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High Respiratory Frequency is Necessary for Survival on Mt. Everest
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