In the protonated form lidocaine does not freely leave cells until it is

In the protonated form lidocaine does not freely

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4.In the protonated form, lidocaine does not freely leave cells until it is metabolized. Since lidocaine can freely diffuse into the cell, why does it not diffuse back out when lidocaine levels drop over time in the region of administration (refer to structural differences in Figure 4)? 5.α-latrotoxin, a neurotoxin in black widow spider venom, also affects acetylcholine (ACh) stimulation of muscle. Interestingly, organisms injected with α-latrotoxin exhibit uncontrollable muscle cramps and spasms, which after some time is then followed by complete flaccid (relaxed) muscle paralysis. Considering what you know about the botulinum neurotoxin, hypothesize how α-latrotoxin may modulate exocytosis of ACh.Conclusion
A BOTCHED BOTOX11To conclude,the topic of this case study was to explore the membrane structure, transport, and signaling via membrane to bound receptors are intimately associated with the paralysis of muscle targeted by botulinum neurotoxin. This case study includes scenarios that revolves around a fictitious socialite that has requested the assistance of her personal concierge physician with a condition that has developed after having participated in a Hamptons Botox party. As said in the case study,Exocytosis and endocytosis are considered active transport because like BoNT exocytosis inhibits the active transport ACh into a synapse and the muscle onthe postsynaptic side relies on the ACh to bind to ACh receptors on the muscles to stimulate contraction ( Adam J. Kleinschmit, 2017). The physician and a shadowing pre-med undergraduate talk about the molecular mechanisms behind Botox induced muscle paralysis.The results A suggestion would be that when reading to take the time to look up and define each word that a person may not understand.
A BOTCHED BOTOX12BibliographyAcetylcholine Receptors. (n.d.). Retrieved November 02, 2017, from Kirchhausen1, T., & And, D. O. (1970, January 01). Tom Kirchhausen. Retrieved November 02, 2017, from Uniporters, symporters and antiporters. (n.d.). Retrieved November 02, 2017, from -transport/v/uniporters-symporters-and-antiportersWhat is uniport, symport, antiport membrane transport? | Socratic. (n.d.). Retrieved November 02, 2017, from -transportWu, L., Hamid, E., Shin, W., & Chiang, H. (2014). Exocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms. Retrieved November 02, 2017, from

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