Conclusion: About half of the SNPs showed considerable differences in allele frequencies between Chinese and Spanish, whereas only minimal differences were found between Spanish and French. These differences in allele frequencies of SNPs in candidate genes may affect their relative roles in the pathogenesis of cardiovascular and related diseases, leading to interethnic differences in the disease pattern, prevalence and response to treatment. This study suggests that apart from studying common SNPs, searching for novel SNPs specific for different ethnic groups is necessaryto understand the association between candidate genes and diseases. Source: Abstract, HGM2002
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