{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Population Genetics

Cardiovascular disease-associated genes 1 maggie c.y

Info iconThis preview shows pages 87–92. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: cardiovascular disease-associated genes 1 Maggie C.Y. Ng , 1 Ying Wang, 1 Wing-Yee So, 2 Suzanne Cheng, 3 Robert Y.L. Zee, 4 Klaus Lindpaintner, 1 Juliana C.N. Chan The Chinese University of Hong Kong , 2 Roche Molecular Systems, Alameda, CA, U.S.A. , Brigham and Women's Hospital, Harvard Medical School, Boston, MA, U.S.A. , 4 Roche Genetics, Hoffmann-La Roche, Basel, Switzerland. Conclusion: About half of the SNPs showed considerable differences in allele frequencies between Chinese and Spanish , whereas only minimal differences were found between Spanish and French. These differences in allele frequencies of SNPs in candidate genes may affect their relative roles in the pathogenesis of cardiovascular and related diseases , leading to interethnic differences in the disease pattern, prevalence and response to treatment. This study suggests that apart from studying common SNPs, searching for novel SNPs specific for different ethnic groups is necessary to understand the association between candidate genes and diseases. Source: Abstract, HGM2002 Ethnic-Difference Markers for Use in Mapping by Admixture Linkage Disequilibrium • Collins-Schramm, Phillips, Operario, et al. • Am J Hum Genet. 70(3): 737–750, 2002 What is Race/Ethnicity? Are not we all Americans from Africa? • Population genetics? – time since migration from Africa • Cultural? – Linguistic homogamy? – social • Religion? • What is Hispanic? – Argentina – Bolivia – Miami • Admixture Race/Ethnicity Prediction?? SNP-based Ethnicity Triangle Plots Maximum Likelihood Analysis see www.ancestrybydna.com Derrick Todd Lee • Arrest of suspect in LA serial homicides • traditional profiling implicated white male • SNP profiling indicated otherwise...
View Full Document

{[ snackBarMessage ]}

Page87 / 92

cardiovascular disease-associated genes 1 Maggie C.Y Ng 1...

This preview shows document pages 87 - 92. Sign up to view the full document.

View Full Document Right Arrow Icon bookmark
Ask a homework question - tutors are online