Increases the absorption of iron o Deficiency: Scurvy Scurvy: gums bleed, sores all over the body, could result in death The sailors who took Jacques Cartier on his second voyage to what became known as new France fell in December 1535 from scurvy as they lacked fruits and vegetables from their diet (their diet on the boat did not include many fruits and vegetables) The natives gave a solution: a tea form needles of spruce prevented scurvy o James Lind Found out the most about Vitamin C, should be the one who is credited for Vitamin C discovery The father and the Ship’s physician (the plague of the sailors) Performed the first clinical controlled trial Lind selected six pairs of men to whom he gave either a daily dose of cider, dilute sulfuric acid, vinegar, sea water, a mishmash of garlic, mustard seen and radish root, or two oranges and a lemon. (things they didn’t have in an ocean journey) There was also a control group of men with scurvy who got the regular ship’s rations. Within days, the two men who were lucky enough to have been put on the citrus diet began to recover. So although Lind was not the first to discover a treatment for scurvy, he certainly was the first to document a “clinical trial” showing the effectiveness of the citrus remedy , which he did in his “treatise on scurvy” in 1753. Captain James Cook discovered that when we took sauerkraut, his sailors did no develop scurvy o It wasn’t until 1795, 174 years after James Lind determined that citrus fruit could be used to prevent scurvy, that the British navy
began to provide a daily supply of lime or lemon juice to all its men Why British men were called “limeys” o Albert Szent-Gyorgyi isolated the “antiscorbutic factor” in 1927. After its molecular strucuture was determined by Norman Haworth in 1933 it was named “ascorbic acid” = chemical responsible for preventing scurvy o ascorbic Acid = one specific compound o Szent-Gyorgyi and Haworth: awarded Nobel Prize for discovery of Vitamin C for preventing scurvy o Can Vitamin C treat the common cold? Linus Pauling wrote “Vitamin C and the Common Cold” People looked into it because he was famous however there was no evidence, therefore people looked into it Trials tested on marine recruits and the results were not compelling, even up to 2g Vitamin C/day did not prevent colds for the marines Arctic habitants may benefit since their immune system is low *Some anecdotal evidence that 1 g an hour for four hours at the first sign of a cold can reduce the severity* taking 4g Vit C is not harmful but may cause diarrhea Linus Pauling also wrote “Cancer and Vitamin C”: he was convinced that vit C was critical for the functioning of the immune system and could prevent cancer it is critical for functioning of immune system but this doesn’t mean it can prevent cancer Need to use huge doses: 50 g of vit C/day: Can only treat cancer patients with high doses of vitamin C for patients who have not done well with the first line of therapy o
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