NE102 Lecture Notes 2

Anaphase promoting complex apc destruction of

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Anaphase Promoting Complex (APC): destruction of cohesins – proteins that bind sister  chromatids together Telophase: when the chromosomes arrive at the poles of the spindle and a contractile  ring is formed.  Cytokinesis: when the newly formed cells divide
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Cell Division  Guest Lecture: Lucia Pastorino 19:00 WHAT IF CELLS THAT ARE NOT SUPPOSED OT DIVIDE RE-ENTER THE CELL  CYCLE? Neurons are post-mitotic  1 study: Cdk5 activity is increased in Alzheimer-diseased brains The cell cycle in cells and mature neurons? Can enter the cell cycle but will not complete Won’t undergo mitosis Called neuronal aberrant cell cycle re-entry A permissive event to neurons vulnerability
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