Iii functional assays choices a i only b i and ii c i

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iii. Functional assays Choices: a. i only b. i and ii c. i and iii d. i, ii, and iii Practice Question 1 (1 of 2)
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Explanation for Question 1: The correct answer is b. Reviewers should assess the added value of using genetic testing technology along with known risk factors. Age, sex, and hypertension are examples of known risk factors that may apply to the disease being studied, and genetic tests should be evaluated in context with known risk factors such as these. Practice Question 1 (2 of 2)
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2. Analytic frameworks for evaluating predictive genetic tests only focus on the preanalytic, analytic, and postanalytic factors that affect the test. a. True b. False Practice Question 2 (1 of 2)
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Explanation for Question 2: The statement is false. Analytic frameworks for evaluating predictive genetic tests do include considerations of preanalytic, analytic, and postanalytic factors; however, other factors are also included, such as outcomes, benefits, harms, and the intended use of the test. Practice Question 2 (2 of 2)
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3. The “ E in the ACCE model refers to which of the following: a. Expressivity b. Effectiveness c. Efficacy d. Ethical e. Environmental Practice Question 3 (1 of 2)
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Explanation for Question 3: The correct answer is d. The “ E stands for ethical. ACCE is an acronym for a nalytic validity, c linical validity, c linical utility, and e thical, legal, and social implications. Practice Question 3 (2 of 2)
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This presentation was prepared by Brooke Heidenfelder, Rachael Posey, Lorraine Sease, Remy Coeytaux, Gillian Sanders, and Alex Vaz, members of the Duke University Evidence-based Practice Center. The module is based on Jonas DE, Wilt TJ, Taylor BC, et al. Challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. In: Chang SM and Matchar DB, eds. Methods guide for medical test reviews. Rockville, MD: Agency for Healthcare Research and Quality; June 2012. p. 11.1- 17. AHRQ Publication No. 12-EHC017. Available at . Authors
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Attia J, Ioannidis JP, Thakkinstian A, et al. How to use an article about genetic association: A: Background concepts. JAMA 2009 Jan 7;301(1):74-81. PMID: 19126812. Attia J, Ioannidis JP, Thakkinstian A, et al. How to use an article about genetic association: B: Are the results of the study valid? JAMA 2009 Jan 14;301(2):191-7. PMID: 19141767. Botto LD, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 2000 May 1;151(9):862-77. PMID: 10791559. Brockton N, Little J, Sharp L, et al. N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review. Am J Epidemiol 2000 May 1;151(9):846-61. PMID: 10791558. Burke W, Atkins D, Gwinn M, et al. Genetic test evaluation: information needs of clinicians, policy makers, and the public. Am J Epidemiol 2002 Aug 15;156(4):311-8. PMID: 12181100.
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