To two or more groups that either receive or do not

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to two or more groups that either receive or do not receive the preventive or therapeutic agent. The group that is allocated the agent under study is generally called the treatment group, and the group that is not allocated the agent under study is called the comparison group. Depending on the purpose of the trial, the comparison group may receive no treatment at all, an inactive treatment such as a placebo, or another active treatment. [Morabia A] Characteristics: Studies preventions and treatments for diseases; investigator actively manipulates which groups receive the agent under study. Limitations: Experimental studies are expensive and often infeasible and unethical Appropriate measure of association: Correlation coefficient or chi-square test for association can be used as a measure of association experimental study. References: Morabia A. A History of Epidemiologic Methods and Concepts. Basel : Birkha¨user, 2004, p. 175 Jan P Vandenbroucke, and Neil Pearce, Incidence rates in dynamic populations , International Journal of Epidemiology 2012;41:1472–1479
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