Cancer incidence vs mortality rate more cancer

Info icon This preview shows page 3. Sign up to view the full content.

View Full Document Right Arrow Icon
Cancer Incidence vs Mortality Rate More cancer incidents o Increased incidents ← better detection (screening, tests, etc) But less mortality o Catching it earlier o Progress in cures Gene Mutations in Retinoblastoma Bi-allelic loss of RB1 (1st tumor suppressor cloned) o RB1 inactivation Glow in the retina Clinical Presentations of Childhood Cancer 1 in 14,000 - 20,000 live births 250-500 new cases in US each year 90% of cases < 3 years old Retinoblastoma genome is stable- no secondary cancer mutations Apoptosis in Retinoblastoma Flavopiridol induces retinoblastoma apoptosis UHRF1 may be required to maintain rapid proliferation of cells UHFR1 upregulation may silence tumor suppressors o UHFR1 upregulatio is seen in human retinoblastoma o UHFR1 is overexpressed by P21 in mouse retinoblastoma Epigenetic Landscape & Retinoblastoma Formation Rb1 inactivation leads to rearrangement of landscape Mouse Retinoblastoma E2F1 and E2F3 are required for Retinoblastoma formation o E2F1 TKO and E2F3 TKO → no retinoblastoma seen
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern