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HomeWork 3 s13

15 sulfanilamide structure gerhard domagk discovered

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15. Sulfanilamide structure. Gerhard Domagk discovered this drug, but was not allowed by the Nazis to accept the 1939 Nobel prize for the work, because he was a critic of the regime. He got the prize in 1947. Sulfanilamide was the first antibiotic. It acts as a competitive inhibitor of an enzyme necessary for the synthesis of folic acid. Folic acid is our vitamin B9. 15a. Is folic acid an essential nutrient for bacteria that are killed by sulfanilamide? YES NO Explain your answer. 15b. Is folic acid an essential nutrient for humans? YES NO Explain your answer.
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The following figures are from a recent journal article ( Pharmaceutical Research, Vol. 27, No. 3, March 2010) discussing a potential cholera medication derived from tannin. Tannins are plant compounds found in quantity in certain nuts, red wines and black tea. In this first figure the size of sections of small intestine are shown on the left. A graph of the weight per cm of dissected small intestines is provided to the right. These sections are tied off at both ends to maintain lumen contents. The potential medicine is called PDG ( for penta-m-digalloyl-glucose ) . PBS is the control treatment (saline solution without cholera toxin added). 16a. Why is the cholera treated segment of intestine enlarged? a. Swelling of brush border cells has created an intestinal blockage b. Brush border cells have taken up excessive quantities of water c. Brush border cells have failed to take up sufficient quantities of water d. Brush border cell division has been increased 16b. How does cholera toxin generate disease symptoms? a. By By means of increased auxin and cytokinin activity b. blocking Na+/Glucose co-transporters c. By blocking Cl- channels d. By activating adenylate cyclase e. By inhibiting carbonic anhydrase f. Through cooperativity with PFK
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