Agonists Noncompetitive antagonists Competitive antagonists Drug enzyme

Agonists noncompetitive antagonists competitive

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Agonists Noncompetitive antagonists- Competitive antagonists Drug- enzyme interactions Selective toxicity
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Lock and Key Lock and Key
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Pharmacokinetics Pharmacokinetics The study of absorption, distribution, metabolism (biotransformation), and excretion of drugs
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Onset of drug action Drug half-life Timing of the peak effect Duration of drug effects Metabolism or biotransformation of the drug Site of excretion Pharmacokinetics Pharmacokinetics
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Pharmacokinetics (cont.) Pharmacokinetics (cont.)
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Pharmacokinetics (cont.) Pharmacokinetics (cont.) Critical Concentration The amount of a drug that is needed to cause a therapeutic effect Loading Dose A higher dose than that usually used for treatment Dynamic Equilibrium The actual concentration that a drug reaches in the body
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Dynamic Equilibrium Dynamic Equilibrium The actual amount of drug that reaches the body results for a dynamic equilibrium. Dynamic equilibrium is affected by: A D B E
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Absorption A bsorption What happens to a drug from the time it is introduced to the body until it reaches the circulating fluids and tissues
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Absorption Absorption Administration Affected by route of administration Oral medications affected by presence of food in the stomach Passive diffusion Active transport
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Factors Affecting Absorption Factors Affecting Absorption
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Distribution D istribution The movement of a drug to the body’s tissues Drug’s lipid solubility and ionization- blood brain barrier Perfusion of the reactive tissue Placenta/Breast Milk
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Biotransformation B iotransformation The liver is the single most important site for biotransformation (metabolism). Breaks down medications Helps to prevents medications from causing adverse effects on the body First pass effect
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Excretion E xcretion Removal of drugs from the body Kidneys play the most important role in excretion of medication
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Half-Life Half-Life Half-life is the time it takes for the amount of drug in the body to decrease to one-half the peak level.
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