CourseInfo_2006

Aph162 physical biology laboratory which will be

Info icon This preview shows pages 2–5. Sign up to view the full content.

View Full Document Right Arrow Icon
APh162 - Physical Biology Laboratory, which will be built around a series of experiments which are designed to correspond with material covered in the lecture course APh161. 2 Tentative Course Outline The course outline given below is intended to provide an overall sense of the topics we will cover and the general flow of the course. Certain individual topics might be added or deleted as I see fit. 1. Biology - A Feeling for the Numbers 2
Image of page 2

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Spatial scales. The size of things - molecules, macromolecular assemblies, organelles, cells, tissues, organisms. Temporal scales in cells. How fast? From molecular vibrations to development - a hierarchy of time scales. Balancing the budget of the cell. Mass budget of the cell. Energy budget of the cell. 2. Genome Management Genomes and the Central Dogma. Information content of genomes (aside on central dogma and “the two great polymer languages”). Gene Expression. How much, when, where and how fast? Case studies from metabolism and development. The mechanisms of genetic control. Transcriptional Control. Statistical mechanics of gene expression. The fabled case of the lac operon. The fabled case of the lambda switch. Dynamics of gene expression. Biological Accuracy. Error rates during translation. Kinetic proof- reading. Packing the Genome. Physical size of genomes. Packing the genome in viruses, prokaryotes, eukaryotes. DNA Management During the Cell Cycle. The cell cycle. The machines of replication. Chromosomal territories and DNA seg- regation. The case of ParM and plasmid segregation during cell division. 3. Dynamics in and of Cells Phenomenology of Cellular Dynamics. Dynamics in the cell. Dy- namics of the cell. Enzyme dynamics. Phenomenology of enzyme action. Rate equa- tions. Michaelis-Menten dynamics. Molecular Motors. A rogue’s gallery - translational and rotary motors. Experimental backdrop. What is a muscle and how does it work? Theories of motor action. The case of kinesin. Traffic within cells. 3
Image of page 3
4. Processes at Membranes Membrane Phenomenology. lipids, membrane area, membrane composition, ions and ion transport. Membrane structures and deformation. A tour of vesicles and membranes. The plasma membrane. Mitochondria, the endo- plasmic reticulum and the Golgi apparatus. Modelling membrane deformation - the Helfrich free energy. Curvature management - making vesicles, viral budding and beyond. Ion Channels. Mechanosensation and tension gating. Action po- tentials and voltage gating. 5. Miscellany on Physical Biology Motility. Physical content of cells - how many copies of the vari- ous molecular actors in the cellular drama. The mean spacing of molecules. Signaling and Chemotaxis. Phenomenology of signaling. Statisti- cal mechanics of snip and stitch. The case of chemotaxis.
Image of page 4

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern