Cvds occur almost equally in men and women are the

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CVDs occur almost equally in men and women. Are the leading cause of death in developing countries, as well as developed ones. ACCORDING TO THE WORLD HEALTH ORGANISATION (WHO)
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The macrophages act as a “cleaning” system to stop the cholesterol from being deposited on the walls. This clean-up system is efficient if the increased cholesterol is not too excessive. THE MACROPHAGES, A “CLEAN-UP SYSTEM” LDL Oxidation of LDL Oxidised LDL Macrophage
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If the quantities of cholesterol are very excessive: The macrophages continue to pick up the LDL But, once they have engulfed large amounts, they turn into what is known as “foam” cells. These induce inflammation and the proliferation of cells in the artery wall Formation of the atheromatous plaque HOW DOES AN ATHEROMATOUS PLAQUE FORM? Foam cell Oxidised LDL Oxidation of LDL LDL Macrophage Immune system activation Proliferation of endothelial cells
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RESEARCH INTO ATHEROSCLEROSIS One of the objectives is: To understand how macrophages are involved in the regulation of cholesterol levels and what role they play in the development of atherosclerosis. ?
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STUDY OF THE LDL RECEPTOR AND MYLIP We know that the macrophages recognise oxidised LDL thanks to some receptors.
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  • Fall '19
  • Atherosclerosis

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