16 The enzymes that cut the DNA into smaller pieces are enzymes 17 True or

16 the enzymes that cut the dna into smaller pieces

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16. The enzymes that cut the DNA into smaller pieces are _______________ enzymes. 17. True or False: If a boy does not have an inversion mutation, the cause of his hemophilia can still be determined with gel electrophoresis. 18. Many labs will use ____________ to determine mutations in hemophilia B.
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93 PBS Documentary: The Human Race Objectives Following the video “The Human Race,” the student will be able to answer the following study questions: 1. Who discovered DNA fingerprinting? 2. Fred Sanger began developing his sequencing method by cracking the code to _______________. 3. In 1998, Craig Venter announced he was starting a private company to sequence the genome. What was his issue with the way things were going in the public sector? 4. Did the public and private sectors work together on the Human Genome Project? 5. Did the public or private sector first use automated DNA sequencing to map the human genome? 6. Which U.S. president sent a mediator to end the feud between the public and private sectors working on mapping the genome? 7. What year was the first draft of the human genome announced?
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94 Lecture 16: Exam 3 Review Complete this study guide to review for Exam 3. 1. Define the following terms: a. Polymorphism b. Mutation c. Genotype d. Phenotype e. Euploid f. Aneuploidy g. Karyotype h. Genome i. Gene j. Chromosome 2. List three categories of DNA mutations and explain what is affected in each. 3. Label the following on the chromosome: telomere (2), centromere, p arm, q arm, gene region
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95 4. What is a sub-metacentric chromosome? Telocentric? Acrocentric? 5. If the location of a certain part of Chromosome 17 is located on the q arm, region 1, band 1, sub- band 2, how would that be written? 6. What is a karyotype and how is it used in the clinical lab? 7. Fill in the blank with the correct chromosomal mutation: a. _______________ is the exchange of genetic material between chromosomes. b. _______________ is the loss of chromosomal material. c. _______________ is the gain of chromosomal material. d. _______________ is the excision, flipping, and reconnecting of chromosomal material within the chromosome. e. _______________ is a chromosome containing two copies of the same arm and a loss of the other arm. f. _______________ results from a deletion of genetic regions from ends of the chromosome and a joining of the ends to form a ring. 8. Karyotyping analysis results are expressed as the number of chromosomes per nucleus, followed by sex chromosomes, followed by any genetic abnormalities. How would a normal male and female karyotype be expressed? 9. If a male had an extra chromosome 21, how would that karyotype be written? 10. If a female had a deletion in the q arm of chromosome 7 at region 1, band 3, how would her karyotype be written? 11. What is the general principle of Fluorescence in situ Hybridization (FISH)? 12. Compare and contrast Interphase FISH and Metaphase FISH. 13. What is a gene mutation? What are some examples of gene mutations? 14. What is a point mutation? List 5 types of point mutations.
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96 15. What is affected in each of the following types of point mutations: a. Silent b. Conservative c. Non-conservative d. Nonsense e. Frameshift 16. What is the general principle of the following biochemical methods for detecting gene mutations: a. Enzyme immunoassays b. Immunohistochemistry c.
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