Copyright 2013 Wolters Kluwer Health Lippincott Williams Wilkins Mechanisms of

Copyright 2013 wolters kluwer health lippincott

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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Mechanisms of Antineoplastic Drugs Affecting cell survival Boosting the immune system in its efforts to combat the abnormal cells
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Goal of Cancer Treatment Destroying cancer cells through several methods: Surgery to remove them Stimulation of the immune system to destroy them Radiation therapy to destroy them Drug therapy to kill them during various phases of the cell cycle
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Categories of Antineoplastic Agents Alkylating Agents React chemically with portions of the RNA, DNA, or other cellular proteins Antimetabolites Have chemical structures similar to those of natural metabolites Antineoplastic Antibiotics Not selective only for bacterial cells; toxic to human cells
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Categories of Antineoplastic Agents (cont.) Mitotic Inhibitors Drugs that kill cells as the process of mitosis begins Hormones and Hormone Modulators Used in cancers that are sensitive to estrogen stimulation Cancer Cell Specific Agents Treat chronic myeloid leukemia (CML) and CD117- positive unresectable or metastatic malignant GI stromal tumors (GIST)
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Question Which term is used to describe the process that occurs when cells lose their cellular differentiation and organization? A. Autonomy B. Neoplasm C. Anaplasia D. Angiogenesis
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Answer C. Anaplasia Rationale: The cancerous cells exhibit anaplasia, a loss of cellular differentiation and organization, which leads to a loss of their ability to function normally.
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Sites of Action of Non Cell Cycle Specific Antineoplastic Agents
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Sites of Action of Cell Cycle Specific Antineoplastic Agents
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