newborn or preterm infant. Exclusively breastfed infants should be monitored if this drug is used during lactation, possibly including measurement of serum levels to rule out toxicity if there is a concern.HaleThus far plasma levels in breastfed infants are undetectable. One case of seizure in a 6 month-old infant. T1/2=8-24h. MW=240. M/P=2.5-8.6. Oral=85%. Cat=L3BriggsLimited human data – potential toxicity.NicotineLactMedWith a 21 mg transdermal patch, nicotine passes into breastmilk in amounts equivalent to smoking 17 cigarettes daily. Lower patch strengths of 7 and 14 mg provide proportionately lower amounts of nicotine to the breastfed infant. No studies on nicotinespray or nicotine gum use in nursing mothers have been reported. Maternal plasma nicotine concentrations after using the nicotine spray are about one-third those of smokers, so milk concentrations are probably proportionately less. Maternal nicotineplasma concentrations after using nicotine gum are variable depending on the vigor of chewing and number of pieces chewed daily, but can be similar to those attained after smoking cigarettes.Some have advocated use of nicotine replacement products in smoking mothers to reduce the risk to breastfed infants of inhaled smoke and toxins in maternal cigarette smoke. However, others point out that based on animal data, nicotine may increase the risk of sudden infant death syndrome and might interfere with normal infant lung development. These authors recommend against using any form of nicotine in nursing mothers. No studies have been performed to resolve these issues. An alternate smoking cessation product may be preferred during nursing.HaleNicotine and its metabolite cotinine are both present in milk with a milk:plasma ratio of 2.9. 15 lactating participated in a trial of the nicotine patch. The authors conclude that Template v5.0
UKDILAS DATABASE TEMPLATEthe absolute infant dose of nicotine and its metabolite cotinine decreases by about 70%
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- Fall '16
- Jeff Miller