The best use for this analysis is when quality of life is the most important factor to be considered; the analysis is commonly used in situations in which the treatment option can be life-extending but have significant side effects. Hepatitis C treatment- There is no vaccine for hepatitis C. Hepatitis C virus (HCV) is the most common chronic blood-borne infection in the United States. HCV transmission occurs by direct percutaneous exposure to infected blood, as well as by occupational, perinatal, and sexual exposure. Newly infected persons with HCV commonly are either asymptomatic or have a mild clinical illness and may not seek medical care. HCV RNA can be detected within 1 to 3 weeks of exposure . Carbamazepine-Anti-convulsant . They are used to treat epilepsy, bipolar affective disorder, aggressive and assaultive behavior, and some neuralgias. They are thought to affect the sodium channels, slowing influx of sodium in the cortical neurons and slowing the spread of abnormal activity. Carbamazepine exerts its effect by depressing transmission in the nucleus ventralis anterior of the thalamus. This area is associated with the spread of seizure discharge. Average peak blood levels of carbamazepine occur approximately 6 hours after administration. Half- life can be as long as 65 hours with initial dosing, but is typically 12 to 17 hours as administration continues. It is noteworthy that the half-life after a single dose is much longer than the half-life after long-term use. Steady state is attained in 2 to 4 days. -Carbamazepine can depress the bone marrow and lead to leukopenia, thrombocytopenia, agranulocytosis, and aplastic anemia. For that reason, a baseline blood screen that includes a complete blood count (CBC), chemistry, liver function tests, and thyroid-stimulating hormone (TSH) test should be obtained, followed by periodic monitoring. -FDA added a Black-Box Warning on the carbamazepine label, recommending testing for the HLA-B*1502 allele in patients with Asian ancestry before initiating carbamazepine therapy because these patients are at high risk of developing carbamazepine-induced Stevens–Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).
Note: For each medication, please be familiar with the use, mechanism of actions, contraindications, adverse reactions, drug interactions, safety/monitoring, pregnancy and lactation, black box warning, etc. 4567
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- Adverse drug reaction, ACEIs