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consequence of surgery. There is a significant amount of literature related to preventing SSIs, andit is up to practitioners in each care setting to review the evidence and work together to implement SSI prevention measures, such as nasal decolonization, antibiotic prophylaxis, preoperative showers, preoperative oxygen supplementation, and antimicrobial sutures. In addition, practitioners can follow several recommendations to reduce the risk of SSIs, including following proper hand hygiene practices; wearing clean, facility-laundered scrub attire; following a surgicalsafety checklist; and speaking up when a break in steriletechnique is witnessed. The benefits of preventing SSIs are preventing patient mortality and decreasing the
SURGICAL SITE INFECTIONS (SSI)7burden that SSIs pose on the national health care system. It is up to health care leaders to drive and support SSI prevention initiatives.Tasya Anggrahita, Aditya Wardhana, & Gentur Sudjatmiko. (2017). Chlorhexidine-alcohol versus povidone-iodine as preoperative skin preparation to prevent surgical site infection:a meta-analysis.Medical Journal of Indonesia,26(1), 54–61. -org.lopes.idm.oclc.org/10.13181/mji.v26i1.1388Abstract: Background: Surgical site infection remains substantial problems to surgeons and patients as it increases the morbidity, mortality, length of stay, hospital cost, rate of re-admission,and rate of re-surgery. This study aims to compare the use of chlorhexidine-alcohol versus povidone iodine for preoperative skin preparation to prevent surgical site infection. Methods: The literature search was conducted through the PubMed database on November 2015. Included studies were RCTs with the year of publication up to 2015 which compared the use of chlorhexidine-alcohol versus povidone-iodine in its effectiveness reducing surgical site infection in adult patients. The quality of the study was assessed using Jadad Score. A meta-analysis was conducted in the included study to obtain a pooled estimate of the effect size. The evidence of heterogeneity and publication bias was also assessed. Results: Six RCTs with a total of 2,080 patients were included in the meta-analysis. It showed that the use of chlorhexidine alcohol was associated significantly with fewer SSIs (pooled risk ratio=0.60 (95% CI=0.45-0.79)) and fewer positive skin culture results (pooled risk ratio, RR=0.38 (95% CI=0.28- 0.51)) compared with povidone iodine. Conclusion: Preoperative skin antisepsis with chlorhexidine is more effective than povidone-iodine in preventing surgical site infection.