Monocytes become macrophages when they enter the tissue They are responsible

Monocytes become macrophages when they enter the

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different from neutrophils and eosinophils. Monocytes become macrophages when they enter the tissue. They are responsible for presenting antigens to the CD4 cell which triggers T cell immunity and the T cell immunity goes on to trigger B cell immunity. Also monocytes release the following cytokines: o IL1 causes fever, activates phagocytes & lymphocytes and also increases the release of IL 6 o IL6 stimulates the production of acute phase reactants and promotes the growth and stimulation of blood cells. 1 TNF can cause fever, increases the synthesis of proinflammatory proteins by the liver, causes muscle wasting and induces thrombosis. Growth Factors promote the production and maturation of neutrophils. As we move through the course you will see that the pathophysiologic basis of many disorders is inflammation. Such diseases include asthma, autoimmune diseases, lupus, rheumatoid arthritis, gout, atherosclerosis, cerebral edema, cirrhosis, and hepatitis to name just a few. Inflammation can be acute or chronic. When it becomes chronic it becomes more of a pathological process rather than a physiologic process and causes permanent damage to the cells/tissues, and causes scar tissue. Coagulation Cascade
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  • Fall '15
  • david,mary
  • CASCADE, Mast Cell Degranulation

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