Proteins larger sphere more lipid lower density

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proteins; larger sphere- more lipid – lower density; chylomicrons, VLDL, LDL, HDL; larger molecule--- >fat contained w/in ---lower density; if low protein then you’ll have low density
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APOLIPOPROTEIN = on surface of lipoprotein- structural and activation of inhibitors for enzymatic rxs; similar to antigens; help distinguish diff. types of particular lipid CHYLOMICRONS = largest and least dense; (high lipid content; low protein content; low density); carry absorbed dietary lipids to the liver LIPID ARTERIOSCHLEROSIS = depositions of cholesterol in artery walls (plaque buildup); high LDL, low HDL; lipid deposition----fatty streaks (thin streaks of excess fat in macrophages in the sub-endothelial space) ----fatty streaks develop over time into plaque (obstruction of blood flow); Drugs---statin-block intracellular cholesterol synthesis/stimulate production of receptors; have hepatic toxicity 2. Diagram and explain the lipoprotein metabolism process, including the four pathways and the functions of Cholesterol, Triglycerides, HDL, LDL, VLDL and chylomicrons. LIPID METABOLISM PROCESS = ABSORPTION PATHWAY---fats ingested mostly as triglycerides (water soluble); triglycerides converted to more water soluble form; packaged w/ bile acids in intestine=micelles EXOGENOUS PATHWAY---micelles absorbed thru intestines and are transported by albumin/chylomicrons to the liver (from intestines to the liver)
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Lipids and Lipoproteins ENDOGENOUS PATHWAY----packaged triglycerideds tacked onto carrier protein-VLDL molecule which is converted to LDL protein thru process---receptor molecules on LDL allow entrance w/in cells (liver to cells) REVERSE CHOLESTEROL TRANSPORT PATHWAY--- anything not utilized and in excess in cell is carried back to liver to be excreted into bile to be eliminated by the HDL (cell back to liver) CHYLOMICRONS---largest and least dense, made by intestines, carry absorbed dietary lipids to liver; involved in the exogenous pathway VLDL---made in liver, transports triglycerides from liver to peripheral tissue; involved in the endogenous pathway LDL---transports cholesterol to cells—LDL receptors; involved in the endogenous pathway HDL---made in liver and intestines; carries excess cholesterol back to liver 3. Define hyperlipoproteinemias-Hypercholesterolemia, Hypertriglyceridemia, Combined Hyperlipoproteinemia, hypolipoproteinemia, hypoalphlipoproteinemia, Elevated Lipoprotein (a); list specific lipid and lipoprotein, and apolipoprotein decreases or increases associated with each, as well as treatments for each. HYPERCHOLESTEROLEMIA = familial-genetic; Cholesterol elevation is primarily associated w/ an increase in LDL cholesterol; individuals synthesize intracellular cholesterol normally but lack or are deficient in active LDL receptors, consequently LDL
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