So oxygen can’t get to blood and thus you die f.i.12.CO2 binds to N terminate f.i.12.a.Decreases hemoglobin’s affinity for oxygen f.i.13.H+ binds to the R group f.i.14.10thstatef.i.14.a.Hemoglobin to unload oxygen g.RBC Life Span and Circulation g.i.90% of red blood cell will be destroyed by macrophages g.ii.10% of red blood cells will die by tissue wore out g.ii.1.Hemolysis g.iii.Macrophages g.iii.1.They conserve hemoglobin g.iii.2.Amino acids are released from the enzymes that cut up thered blood cells that are free to roam around g.iii.3.Heme group is released from the enzymes that cut up the red blood cells, so heme is converted to bilirubing.iii.4.Bilirubin g.iii.4.a.People who have diseases in the liver have problems making bilirubin, which can be leeway to jaundice. g.iii.4.b.Excreted in urine causes pee to be yellow g.iii.4.c.Excreted in our poop, poop should be yellow? g.iii.4.c.i.No because bilirubin is modified by bacteria (urobilins and stercobilins), converted to brownish like pigmentg.iv.RBC Production g.iv.1.Erythropoiesis occurs in bone marrow g.iv.2.Vitamin B12 g.iv.2.a.Coenzyme in the production of red blood cells
g.iv.2.b.If you lack V12 you will be anemic g.iv.3.Pernicious anemia g.iv.3.a.Disease where stomach doesn’t produce enough GIF (gastric intrinsic factor), protein that binds V12 and takes it all the way up to the small intestine and facilitate itsabsorption, without GIF you won’t have proper V12 in the proper and thus you have anemia g.iv.3.b.Treatmentg.iv.3.b.i.Frequent injections of V12 in your plasma g.iv.4.Polycythemia g.iv.4.a.Elevated hematocrit g.iv.5.Anemia g.iv.5.a.Low hematocrit g.iv.6.Thyroid and growth hormone stimulate erythropoiesis g.iv.7.Polycythemia vera g.iv.7.a.Hyperplasica in your bone marrow (cancer) g.iv.7.b.Making too many blood cells g.iv.8.Red Blood Cells don’t have nucleus g.iv.8.a.How does it live? g.iv.8.a.i.No organelles and nucleus so it lives 120 days because it has glycolysis to get ATP to sustain itselfg.v.Blood Typesg.v.1.Type A g.v.1.a.A antigens on the surface of blood cells (carbohydrates) g.v.2.Type B g.v.2.a.B sugarsg.v.3.Type AB g.v.3.a.A and B sugars
g.v.3.b.Universal recipient g.v.3.b.i.If you are prone to vascular injuryg.v.3.b.ii.You can’t have antibodies in the blood so there won’t be gluctination g.v.4.Type O g.v.4.a.No sugars g.v.4.b.Lack of antigen g.v.4.c.Universal donor g.v.4.c.i.Give your blood to anyoneg.v.4.c.ii.Because red blood cells don’t have any sugars on the surface g.v.5.If you have antigen you cant have antibody of that g.v.5.a.So type A you have B antibody and type B you have A antibody g.v.6.Aggulutinogens g.v.6.a.Antigensg.v.7.Agglutinins g.v.7.a.Antibodies g.v.7.b.Bind to the aggulutinogens which cause the cluster of blood cells called glucenation which leads to hemolysis (red blood cell death) g.v.8.RH antigen g.v.8.a.RH factor (D Antigen) g.v.8.b.Significance when talking about labor g.v.8.b.i.If an individual is RH positive they have D antigen g.v.8.b.ii.