lecture 2 review handout with answers

What does it mean for a cell to be fated fate

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What does it mean for a cell to be “fated ”? Fate describes how the cell would normally develop, and can be traced by following individual cells during development to see what they become. Fate does NOT dictate the state of commitment in a cell 4. What does it mean for a cell to be “committed ”? Requires an operational test to distinguish between specification and determination. Specification Test: If when isolated from embryo and cultured in a NEUTRAL environement cell develops according to its normal fate. Presumptive eye region of BLASTULA when neutrally cultured does not express gene characteristics of eye differentiation, yet the presumptive eye region of a GASTRULA, when neutrally cultured expresses genes characteristics of eye differentiation.
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Determination: A stable change inn the internal state of a cell, an irreversible commitment to a specific fate, heritable upon division. Test: transplant cells to a challenging environment. Presumptive eye region of GASTRULA adopts regional characteristics (rather than eye characteristics). Presumptive eye region of NEURULA retains eye characteristics upon transplantation to challenging environment.
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What does it mean for a cell to be fated Fate describes how...

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