HSC 332 ch.10 outline.docx

O alveolar sites have a large surface area for gas

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o Alveolar sites have a large surface area for gas exchange. o There is a small diffusion distance making gas exchange occur rapidly. o Gas moves across the blood-gas interface in lung through diffusion. o The rate of diffusion is described by Fick`s law. The volume of gas that moves across a tissue is directly proportional to the area for diffusion, the difference in partial pressure across the membrane and is inversely proportional to membrane thickness. Discuss the major transportation modes of 02 and co2 in the blood. o 10% of CO2 is dissolved in plasma, 20% of CO2 is bound to hemoglobin, and 70% is transformed into bicarbonate. o The amount of O2 that can be transported per unit volume of blood is dependent on the concentration of hemoglobin. o Approximately 99% of O2 is transported in the blood bound to hemoglobin. Oxyhemoglobin : O2 bound to hemoglobin. Deoxyhemoglobin: O2 isn`t bound to hemoglobin. Discuss the effects of increasing temperature, decreasing pH, and increasing levels of 2-3 DPG on the oxygen hemoglobin dissociation curve. o One of the resulting products of red blood cell glycolysis is 2-3 DPG. This molecule has the capability to combine with hemoglobin to reduce hemoglobin’s affinity for O2.
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o Red blood cells do not have a mitochondria or a nucleus which means they must rely on anaerobic glycolysis to meet energy requirements.
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