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Lecture_10-GABA_Lecture

Gabaergic terminal vesicular packing through

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GABAergic terminal -Vesicular packing through vesicular GABA transporter -synthesis in neuron terminals -catabolism in neuron terminals and in astrocytes
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Affecting GABA uptake Storage and Release -release is Ca2+-dependent -release can be inhibited by autoreceptors -vesicular transporter is distinct from the membrane transporter Reuptake -low and high affinity reuptake mechanisms -high affinity is Na+-dependent (action potential will actually induce a brief GABA release); transport can go in 2 directions -Cl- dependent -GAT-A (GAT-1) and GAT-B PM transporters (neurons and glia) - Tiagabine : reuptake inhibitor
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GABA projections in brain -10-40% of terminals in cortex, hippocampus & substantia nigra use GABA -rich in: Cerebellum, Striatum, Globus pallidus Olfactory bulbs GAD GABA GABA-T
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