28 29 Regulation of Body Metabolism and Temperature

Glucose c6h12o6 6 o2 6 co2 6 h2o 35 respiratory

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Glucose (C6H12O6) + 6 O2 6 CO2 + 6 H2O kcal/g 3.8 9.1 3.5 Respiratory Quotient (RQ) (VCO2/VO2) 1.0 ~0.7 ~0.8 Carbohydrate Fat Protein RQ = 6CO2 / 6O2 = 1 Eicosapentaenoic Acid (C20H30O2) + 26.5 O2 20CO2 + 15H2O RQ = 20CO2 / 26.5O2 = 0.75
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T3 Effects on Cardiac Myocyte (From: Circulation 116: 1725-1735, 2007) Nongenomic Effects of Thyroid Hormone : Direct Modulation of Ion Channels and Na-K-ATPase Genomic Effects of Thyroid Hormone: Stimulating Gene Expression of: Myosin Heavy Chain SR Ca2+-ATPase Na-K-ATPase Beta-Adrenergic Receptor Voltage-Gated Potassium Channels
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Body Temperature Homeostasis
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Variation of Body Temperature with Time of Day
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Temperature Variations During Menstrual Cycle (From: MCN Am J Matern Child Nurs 30: 290-296, 2005)
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Menopausal Hot Flashes Due to Narrowing of the Thermoneutral Zone (From: Am J Ob Gyn 196: 97-106, 2007)
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Summary of Temperature-Regulating Mechanisms
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Fever and Hypothermia
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37 39 Body temperature, oC 0 1 2 3 4 5 6 Time in hours Set point suddenly raised to high value Chill phase: vasoconstriction piloerecton sympathetics shivering behavior Set point suddenly reduced to low value Recovery phase: vasodilation sweating behavior Actual body temperature Set point temperature Fever: Set Point Change
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Peripheral Mechanisms by which Infection Causes Change in Temperature Setpoint
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COX-2 and PGE2 in Fever Generation (From: Am J Med 111: 304-315, 2001)
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Mechanisms of Antipyretics (From: Am J Med 111: 304-315, 2001)
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Thermal Changes During Exercise
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Hyperthermic Athletes and Heatstroke Victims Cooling Rates Associated with Various Modalities (From: Exerc Sport Sci Rev 35: 141-149, 2007)
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Induced Hypothermia (32-35oC) Improves Outcome in Cardiac Arrest Patients (from: Lancet 371: 1955-1969, 2008)
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