And c phenacetin or d acetanilide 2 sucrose is

and C) Phenacetin or D) Acetanilide
2. Sucrose is soluble_ in diethyl ether 3. What is the purpose of using “Craig tube” in this Lab? 4. Panacetin is a mixture of three compounds, when treated with Dichloromethane or diethyl ether Sucrose remains as a solid.
5. Aspirin is soluble_ in diethyl ether
6. Describe what is the purpose of using a “Craig tube” in this Lab?
7. Panacetin is a mixture of three compounds, when treated with Dichloromethane or diethyl ether followed by NaHCO3
_____________________ stays in the organic layer.
8. Sucrose is insoluble_ in diethyl ether
9. Aspirin is soluble_ in diethyl ether
10. Complete the reactions below

PURPOSE: To Identify the components of "Panacetin" and determine the composition of the mixture.
LEARNING OBJECTIVES : To learn how to purify solids by recrystallization, how to dry them, and how to obtain a melting
point. To learn and understand some basic concepts relating to the purification and analysis of organic compounds.
INTRODUCTION : Commercial Panacetin is an antipyretic drug which is comprised of aspirin (200mg), acetaminophen
(250mg), and sucrose (50mg) If produced outside U.S. it could contain acetanilide or phenacetin (Pain killing compounds
banned in U.S. due to toxicity). In our case, your Panacetin, is a mixture of three compounds: acetylsalicylic acid (aka
aspirin), acetanilide or phenacetin (referred as “unknown” in the rest of the document) , and sucrose. In lab 2 you had
separated a mixture of Panacetin into separate pure compounds and determined the composition of each component in the
drug. In this lab you will be identifying the unknown component (acetanilide or phenacetin) by melting point analysis.
N
H
O
HO
ACETAMINOPHEN
N
H
O
H
3
CH
2
CO
PHENACETIN
N
H
O
ACETANILIDE
Lab 3 CHE 201 Summer 2014-Ahsan 8
Lab 4: Identifying the Constituents of Panacetin [Lehman Exp 3 page 18]
1. An unknown compound X is one of the four compounds listed in the following table. A mixture of X with benzoic
acid melts at 89°C, a mixture of X with phenyl succinate melts at 120°C, and a mixture of X with m -aminophenol
melts at 102°C. What is the identity of X? Explain.
The unknown is phenyl succinate . The
melting point of the unknown-phenyl succinate
mixture is close to the reported value for phenyl
succinate, whereas the melting point of the other
mixtures are lower than the reported values for the
pure compounds.

(1) What is the minimum volume of Boiling water needed to dissolve 0.2 g of Phenacetin,
Solubility of Phenacetin =1.22 g/100 ml boiling water
0.2 g x 100 ml/1.22 = 16.4 ml
(2) How much Phenacetin will remain undissolved when the above solution is cooled to room temperature.?