BIO314 Full Practice Exam 2

The ras effecter pathway a is dependent on the

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3) The Ras effecter pathway… a) …is dependent on the activation of Ras from a GDP bound state (inactive state) to a GTP bound state (active state) from its (inactive Ras’s) interaction with a guanine neucleotide exchange factor (GEF), i.e. the proximity of Son of Sevenless (SoS). b) …can activate Raf (MAPKKK) and initiate a kinase cascade that sees the phosphorylation of serines (S) and tyrosines (Y), which leads the activation of early genes. c) …is involved in many signaling cascades, three of which are the PI3Kinase (PI3K) cascade, which inhibits apoptosis (pro-survival) and promotes proliferation, the Raf pathway, which promotes chromatin remodeling and , and the Ral-GEF pathway, which is responsible for the epithelial to mesenchymal transition (EMT). d) …does what is described in Choices A and C.
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e) …does all of the above. 4) Which of the following is true about the powerful signaling kinase Akt/PKB? 5) Of the following, which is an incorrect statement? 6) Of the following, which is a correct statement?
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