Amino butyric acid meet criterion for a

Info icon This preview shows pages 3–7. Sign up to view the full content.

View Full Document Right Arrow Icon
-amino-butyric acid) Meet criterion for a neurotransmitter: 1) synthesized within neurons 2) packaged and stored within neurons 3) released from neurons upon depolarization 4) also have transporters for reuptake ***all of the above also true for astrocytes
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
-Aminobutyric acid (GABA) - GAD (glutamate decarboxylase) converts glutamate to GABA (requires pyridoxal phosphate as cofactor) -enriched in cytosol and synaptosomes (terminals) -2 isoforms GAD65* and GAD67 (90% sequence homology) - GABA-T (GABA aminotransferase or GABA transaminase) -mitochondrial enzyme; cytosol of neurons and astrocytes -transfers the amino group from GABA to -ketoglutarate -products are succinic semialdehyde (gets converted into succinate) and glutamate
Image of page 4