For conjunctival irritation the preservative free ocular lubricant is used

For conjunctival irritation the preservative free

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For conjunctival irritation, the preservative-free ocular lubricant is used while for corneal erosions, antibiotic ointments are used [1]. In addition, for chronic blepharitis, moisture chambers and topical lubricants or full-thickness skin grafting to the upper eyelid are considered. On the other hand, soft-bristled toothbrush, normal saline mouth rinses, oral lubrication (petroleum jelly, glycerin, methylcellulose) are recommended. In addition, hormonal treatment for puberty induction will be given in those with delayed puberty. On top of that, for esophageal strictures, endoscopic balloon dilators or fluoroscopy-guided, over-the-guidewire hydrostatic balloon dilators are used to dilate the esophagus [1]. Besides that, surgery is carried out to correct mitten deformity followed by the postoperative use of custom-made splints and hand therapy [1]. On the other hand, there are two ways to treat squamous cell carcinoma which are surgical and nonsurgical such as radiotherapy or chemotherapy and lastly punch grafting for chronic ulcers [1].
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In conclusion, epidermolysis bullosa should manage early especially extensive erosions and complications. Epidermolysis bullosa wounds should use protective atraumatic dressings instead of adhesive dressings to absorb exudates, using a pad on trauma prone areas, removing dressings in water to limit friction, releasing fluid from tense blisters and treating skin infections [1]. Diluted bleach baths or compresses, topical antiseptics, and topical antibiotics bathing are to eliminate the bacteria, body odor and skin exudates [1]. Treatments for mild to moderate pain are acetaminophen and NSAIDs while opioids ( codeine , morphine ) while treatment for severe pain is anxiolytics ( diazepam , lorazepam , midazolam ). Plus, treatments for neuropathic pain are tricyclics amitriptyline, gabapentin, pregabalin, and other antiepileptics [1]. Epidermolysis bullosa patients also require nutritional support [1]. Ocular lesions, oral hygiene and severe complications of epidermolysis bullosa needed to manage and treated well. References 1. Murrell D.F. ( 2019). Overview of the management of epidermolysis bullosa. In: Hand J.L. & Corona R. (Eds.), UpToDate , Waltham (MA). Available from: - search=Epidermolysis %20Bullosa&source=search_result&selectedTitle=1~69&usage_type=default&display_rank=1# H3062885540 2. Boeira V, Souza E, Rocha B, Oliveira P, Oliveira M, Rêgo V et al. Inherited epidermolysis bullosa: clinical and therapeutic aspects. Anais Brasileiros de Dermatologia. 2013;88(2):185-198. 3. Laimer M., Bauer J., Murrell D.F. ( 2018). Epidemiology, pathogenesis, classification, and clinical features of epidermolysis bullosa. In: Hand J.L. & Corona R. (Eds.), UpToDate , Waltham (MA). Available from: ? qurl=- clinical-features-of-epidermolysis-bullosa%3fsearch%3dEpidermolysis%2520Bullosa%26source %3dsearch_result%26selectedTitle%3d2~69%26usage_type%3ddefault%26display_rank%3d2
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4. SALAVASTRU C, SPRECHER E, PANDURU M, BAUER J. Recommended Strategies for Epidermolysis Bullosa Management in Romania. National Center for Biotechnology Information, US National Library of Medicine [Internet]. 2013 [cited 18 March 2020];8(2):200– 205. Available from:
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  • Winter '19
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  • epidermolysis bullosa

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