Insufficient clotting o Platelet disorder thrombocytopenia Autoimmune disease

Insufficient clotting o platelet disorder

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Insufficient clotting:oPlatelet disorder:thrombocytopenia:Autoimmune disease, chemotherapy, folate/B12 deficiencyoCoagulation disorder: Hemophilia A and B: Genetic disorder (X-linked); factor VII or IX deficiencyVitamin K deficiency:newborns, acquired due to malnutrition, malabsorptionHepatic disease:common complication of many hepatic diseasesExcessive clotting: oThrombus: stationary blood clot within a vessel. Arterial: ischemia or Venous: edema (blocks removal of metabolic waste andthrombophlebitis (inflammation of vein).oEmbolus: traveling clot produce new site of obstruction. Most originate in the deep vein right side of the heart arterialside of pulmonary vasculature pulmonary emboli.Left side of heart cerebral artery stroke.Disseminated intravascular coagulation (DIC):oParadox of thrombosis and hemorrhage at the same time. Increased intravascular clotting (major injury, chronic inflammation, damaged epithelium cells). Coagulation factors rapidly consumed bleeding and microthombi kidney function
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