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oxygen to create the corrosive gas nitrogen dioxide (NO2). This is converted to nitric acid and leads to “acid rain.”Biological NO:-extremely reactive and potentially dangerous free radical produced by the bodyHistory of Clinical Application of “NO”-nitroglycerin is a component of dynamite-that was created by Alfred Nobel-use of dynamite during war caused Alfred Nobel to create the Nobel PeacePrize-in late 1800’s nitroglycerin was administered in a diluted form to help people with cardiovascular problems; for the last 2 months of his life Alfred Nobel was treated for angina with dilute nitroglycerin (Trinitrin) -in 1970’s the secret of nitroglycerin’s relationship with NO emerged and NO identified as a signaling molecule released by endothelia cells that relaxed blood vessles and . -The 1998 Nobel Prize in Medicine was awarded to Robert Furchgott, Ferid Muradand Louis Ignarro for their discoveries in how NO regulated the muscle tone of blood vessels in the cardiovascular system. -Endothelium-Derived Relaxing Factor (EDRF)
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