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lymphatics and immune notes

During a fever liver and spleen sequester iron and

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During a fever, liver and spleen sequester Iron and Zinc, which are needed by bacteria to reproduce. * Increased cellular metabolic rate promotes healing. * Increased temperature further activates macrophages. But..too much .... Too high of a temperature can denature enzymes (>104∞F). II. The Adaptive (specific) Immunity (Ch 33 - Fig 33-3 ) -specificity- involves specific B and T lymphocytes -versatility (can attack most anything) -memory -tolerance (disguishes self from non-self) -B cells (Humoral) and T cells (Cell-Mediated)
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Box 33-1 Terms of the chapter.. .. Antigen = large, complex molecule not normally present in the body. Referred to as NON-SELF. Specific parts of an antigen, known as antigenic determinants, are the identifiers of the antigen and are the parts of the antigen that stimulate the immune system. A pathogen is a harmful type of antigen. MHC markers —self antigens. Major Histocompatibility Complex proteins on the surface of body cells. The markers are genetically determined and identify cells to the immune system as SELF cells. If there is a problem with the MHC marker, the cell will be killed. Naïve - inactive B or T cells. Clone - family of cells descended from one cell MHC I = found on all body cells except RBC’s. MHC II = found on surface of mature B cells, some T-cells and antigen-presenting cells (APC's- macrophages and neutrophils (phagocytes). Antigen presenting cells phagocytize invaders and save a piece of antigen for lymphocytes. A. T-cells and Cell-Mediated Immunity . (Fig 33-17) 1. Helper T-cells only recognize cells with type II MHC proteins (WBC’s); stimulate proliferation of other Tcells and B-cells already bound to antigen. 2. Cytotoxic T-cells (killer cells).: only recognize cells with MHC I proteins; kill virus infected or other foreign agent infected cell (fig 33-16).Kill with a lethal hit by releasing chemicals into target cell that causes cell lysis . Also go through clonal selection. 3. Suppressor T-cells: Release of lymphokinins that suppress the activity of both T and B cells.
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