B Warn the patient that GI upset nausea and vomiting are to be expected C Start

B warn the patient that gi upset nausea and vomiting

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B. Warn the patient that GI upset, nausea, and vomiting are to be expected. C. Start taking the medicine as soon as possible to improve effectiveness of antiviral activity. D. Be sure to take most of the medication prescribed to improve effectiveness of antiviral activity.
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Answer C. Start taking the medicine as soon as possible to improve effectiveness of antiviral activity. Rationale: Administer the drug as soon as possible after the diagnosis has been made to improve effectiveness of the antiviral activity.
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Drugs Used to Treat HIV/AIDS • Reverse Transcriptase Inhibitors • Protease Inhibitors • Nucleosides • Fusion Inhibitors
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Reverse Transcriptase Inhibitors • Action – Bind directly to HIV reverse transcriptase blocking both RNA and DNA dependent DNA polymerase activities • Pharmacokinetics – Given orally, metabolized in the liver, excreted in the urine • Contraindications – Pregnancy and lactation • Adverse Reactions – Headache, nausea, vomiting, rash, chills, fever, diarrhea
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Protease Inhibitors • Action – Block protease activity within the HIV virus • Pharmacokinetics • Contraindications – Pregnancy and lactation • Adverse Reactions • Drug-to-Drug Interactions
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Nucleosides • Action – Interfere with HIV replication by inhibiting cell protein synthesis • Pharmacokinetics – Given orally or IV; metabolized in the liver and excreted in the urine • Contraindications • Adverse Reactions – HA, insomnia, dizziness, nausea, diarrhea, fever, rash • Drug-to-Drug Interactions
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Fusion Inhibitors • Action – Prevents the fusion of the virus with the human cellular membrane • Pharmacokinetics – Given sub-q; metabolized in the liver it is recycled in the tissues it is not excreted • Contraindications – No true contraindication • Adverse Reactions – HA, dizziness, myalgia, nausea, vomiting, and diarrhea • Drug-to-Drug Interactions – Pimozide, rifampin, triazolam, midazolam, oral contraceptive
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Prototype of HIV/AIDS Antiviral Agents
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Prototype of HIV/AIDS Antiviral Agents
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Prototype of HIV/AIDS Antiviral Agents
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Prototype of HIV/AIDS Antiviral Agents
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Prototype of HIV/AIDS Antiviral Agents
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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Prototype of HIV/AIDS Antiviral Agents
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