PS 5 Biomolecular Substitution and Elimination.pdf

Does your answer generate the correct stereoisomer of

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• Does your answer generate the correct stereoisomer of the product? products of this transformation CH 3 N O CH 3 H H + LDA, solvent b) CH 3 CH 2 -I, solvent c) workup products of this transformation CH 3 N O CH 3 H H + NaOEt, solvent b) CH 3 CH 2 -I, solvent c) workup A B reacting partner in this transformation O K H this product only- no constitutional or stereoisomers! Ph solvent then workup
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6. Provide the reaction intermediate and the product of the transformation. 7. The structure of an important biomolecule is given below. Briefly explain its general role within biological systems, pointing out its important structural features. 8. Provide the reagent(s) that would carry out the following transformations. EtO 2 C Br EtO 2 C H Ph a) NaH, solvent reaction intermediate + H 2 product of this transformation ( then workup step ) a) NaH, solvent b) workup NH 3 S + O O OH HO O N N H 2 N N N OH O S O O CH 3 a b c O O OH CH 3 OCH 3 CH 3
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9. Draw the major organic product(s) of the following reactions. You should be able to draw the reaction mechanism for ALL of these reactions, step-by-step. K-O t Bu solvent then w/u Li-OEt solvent then w/u Br O O OH Br CH 3 a) K-OCH 3 b) c) workup I H H O OCH 3 O K-OCH 3 solvent then w/u Br Br K-O t Bu solvent then w/u I K-OCH 3 solvent then w/u Br NaO 2 CCH 2 CH 3 solvent then w/u Br Li-SPh solvent then w/u a b c d e f g h
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