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Euphoria cns depression that could lead to

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Euphoria CNS depression that could lead to respiratory depression (this is the most serious adverse effect) Nausea and vomiting Urinary retention Diaphoresis and flushing Pupil constriction (miosis) Constipation Itching Opioid Tolerance
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-A common physiologic result of chronic opioid treatment Differentiate between: Tolerance: the capacity to endure continued subjection Physical dependence: the adaptation of the presence of the opioid causing withdrawal symptoms if not continued Psychologic dependence: an emotional need for a substance with no underlying physical need Opioid Withdrawal: the signs and symptoms associated with abstinence from or withdrawal of an opioid analgesic when the body has become physically dependent on the substance Symptoms: anxiety, irritability, chills and hot flashes, joint pain, lacrimation, rhinorrhea, diaphoresis, nausea, vomiting, abdominal cramps, diarrhea, and confusion Opioid antagonist drugs to reverse respiratory depression: Nonopioid Analgesics Acetaminophen: Has analgesic and antipyretic effects, little to no anti-inflammatory effects, and available OTC Mechanisms of Actions: Blocks pain impulses peripherally by inhibiting prostaglandin synthesis Indications Mild to moderate pain Fever Alternative when cannot take aspirin products Toxicity and Managing Overdose Even though OTC, lethal when overdosed Overdose, whether intentional or resulting from chronic unintentional misuse could cause hepatic necrosis or hepatotoxicity Long-term ingestion of large doses can cause neuropathy Recommended antidote: acetylcysteine regimen Dosage: Maximum daily dose for healthy adults is 4000 mg/day but 2000 mg/day for elderly or those with liver disease Interactions Dangerous interactions may occur if taken with alcohol or other drugs that are hepatoxic Should not be taken in the presence of: drug allergy, liver dysfunction, possible liver failure, and G6-PD deficiency Herbal Products: Feverfew Related to the marigold family and has anti-inflammatory properties – used to treat migraine headaches, menstrual cramps, inflammation, and fever May cause GI distress, altered taste, muscles stiffness May interact with aspirin and other NSAIDS, and ant-coagulants
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Anesthetics: drugs that depress the central nervous system (CNS) normally involve the depression of consciousness, loss of responsiveness to sensory stimulation, and muscles relaxation Aim: a state of depressed CNS activity Two types: General anesthesia: complete loss of consciousness Local anesthesia- localized area that loses pain sensation Balanced anesthesia: gives you relaxation, carelessness, and euphoria General anesthetics: drugs that induce a state in which the CNS is altered to produce varying degrees of Pain relief Depression of consciousness Skeletal muscles relaxation Reflex reduction Inhalational anesthetics: volatile liquids or gases that are vaporized in oxygen and inhaled Inhaled gas: nitrous oxide (laughing gas) Inhale volatile liquids: ethrane, fluothane, forance, and penthrane Parenteral anesthetics:
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Euphoria CNS depression that could lead to respiratory...

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